David Brauer

Research Students (until 2021-12-31)

Projects

Research Projects

Sarcopenia Map

In collaboration with the Division of Gastroenterology at the Rostock University Medical Center (as part of the EnErGie project) we are developing an in-depth, standardized, and computationally encoded disease map of the molecular interactions regulating muscle growth and function. We integrated the two disease states intestinal dysfunctions (ID) and liver cirrhosis (LC) into the map to investigate their contribution to the loss of muscle function (sarcopenia).

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AIR: Atlas of Inflammation Resolution

The AIR is to provide an interactive platform connecting scientific and medical communities.

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GB-XMap: Assessing the risk of gut-brain cross-diseases

Investigating the gut-brain-axis

The gut–brain axis (GBA) provides a bidirectional homeostatic communication between the gastrointestinal tract and the central nervous system. The interdisciplinary collaboration is going to fully explore a first comprehensive GBA cross-disease map of genetic, expression and regulatory changes associated with ulcerative colitis and schizophrenia disease entities.

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de.STAIR: Structured Analysis and Integration of RNA-Seq Experiments

RNA Sequencing (RNA-Seq) has become a widely used tool to study quantitative and qualitative aspects of the transcriptome. The variety of RNA-Seq protocols, experimental study designs and the characteristic properties of the organisms under investigation greatly affect downstream and comparative analyses. We provide easy access to comprehensive analysis of RNA-Seq experiments as a service. To do so, we leverage on the Galaxy framework, and organise dedicated workshops, training programs, and screencasts to make Life Scientists familiar with computational approaches to biological problems.

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Academic background

2020 - present

Research assistant
Department of Systems Biology and Bioinformatics
University of Rostock
Rostock, Germany

2018 - 2020

M.Sc. in Medical Biotechnology
University of Rostock
Rostock, Germany

2014 - 2018

B.Sc. in Medical Biotechnology
University of Rostock
Rostock, Germany

 

Selected publications

In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia

Hoch M, Ehlers L, Bannert K, Stanke C, Brauer C, Caton V, Lamprecht G, Wolkenhauer O, Jaster R, Wolfien M

Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice

Power Guerra N, Parveen A, Bühler D, Brauer DL, Müller L, Pilz K, Witt M, Glass Ä, Bajorat R, Janowitz D, Wolkenhauer O, Vollmar B, Kuhla A

The Atlas of Inflammation-Resolution (AIR)

Serhan CN, Gupta SK, ... , Smita S, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, ... , Wolkenhauer O

A systems appraoch to investigate inflammation resolution by multicomponent medicinal product TR14

Schopohl P, Smita S, Khan F, Gebhardt T, Hoch M, Brauer D, Cesnulevicius D, Schultz M, Wolkenhauer O, Gupta S

Workflow Development for the Functional Characterization of ncRNAs

Wolfien M, Brauer DL, Bagnacani A, Wolkenhauer O

Springer (2019), chapter in Computational Biology of Non-Coding RNA. Methods in Molecular Biology, vol 1912.

Machine-Learning-Assisted Construction of a Disease-Specific Molecular Interaction Network from Human Blood RNA-Seq Data

Brauer DL

Master thesis within the study degree of Medical Biotechnology

Functional Characterization of Long Non-Coding RNAs from Stem Cell Derived Cardiomyocyte Cell Types

Brauer DL

Bachelor thesis within the study degree of Medical Biotechnology