SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
+49 381 498-7571
AIR: Atlas of Inflammation Resolution
The AIR is to provide an interactive platform connecting scientific and medical communities.
Acute inflammation is a nonlinear spatio-temporal process for the removal of invading pathogens and the repair of damaged tissues. If not resolved, it can lead to chronic inflammatory clinical phenotypes. The Atlas of Inflammation Resolution (AIR) provides a comprehensive resource, covering damage-, and pathogen-associated molecular patterns (DAMPs and PAMPs), relevant signaling events, protein-protein interactions and gene regulatory mechanisms underlying acute inflammatory clinical phenotypes. More specifically, the AIR provides:
- An interactive, searchable, scalable, web-based computational representation of acute inflammation and its resolution
- An acute inflammation focused portal to databases such as DrugBank, chEMBL, UniProt, GenBank and Pubmed.
- Thousands of manually curated, directed and experimentally validated interactions, allowing for the identification regulatory motifs, including feedback and feedforward loops.
- A research tool for bioinformatics analyses related to inflammation and inflammation resolutions. Using established standards, like SBML and the Minerva platform , the AIR allows users to map experimental data onto the molecular interaction map and to develop mathematical models for further analysis.
A systems appraoch to investigate inflammation resolution by multicomponent medicinal product TR14
Schopohl P, Smita S, Khan F, Gebhardt T, Hoch M, Brauer D, Cesnulevicius D, Schultz M, Wolkenhauer O, Gupta S