Acute inflammation is the first protective response by the host tissue against invading pathogens and/or injury. It is a highly coordinated, active, nonlinear spatio-temporal process for the removal of invading pathogens and the repair of damaged tissues to reestablish homeostasis. The whole acute inflammatory landscape can be broadly divided into 4 phases, namely, inflammation initiation; transition, resolution and finally homeostasis. The boundaries of all these phases are fuzzy and contain large number of regulators (molecular switches) in the form of feedback and feedforward loops, making the whole system extremely complex and dynamic.

Currently, there is no common web platform for the community to share their viewpoints on the emergence of acute inflammatory phenotypes. We conceptualized Atlas of Inflammation Resolution (AIR) as a community resource to connect clinicians, research scientists, pharmaceutical companies working in the area of acute inflammation and inflammation resolution. This can be realized only when AIR is able to support 1) clinicians in decision making (e.g. patient stratification; therapy response; therapy personalization), 2) research scientists in the development of hypotheses for experimental design (e.g. identification of molecular switches, mapping of high-throughput experimental data), and 3) pharmaceutical companies in the identification of new therapeutic checkpoints.

In the research seminar, I will present the current status and the live demonstration of various features available with the AIR to support inflammation community.