The interconnectivity of immune cells is the subject of extensive research for its importance in many different diseases like autoimmune defects, (microbial) infections and cancer. Many cell types have already been identified which are regulated through a complex network of cytokines and small molecules from which many may have not been discovered yet. It is therefore of great interest to understand these mechanisms as they provide the basis for targeted drug development. This project investigates the methodology for creating and analyzing immune system interactomes using cell type clustered networks based on transcriptomics data.