Clarisse de Vries is a PhD student at the Aberdeen Biomedical Imaging Centre in Aberdeen, Scotland. She is part of the Brain Ageing research group, which focusses on the relationship between life-course variables and brain health later in life. She will discuss the rich Aberdonian datasets (the Aberdeen Birth Cohorts of 1921 and 1936, and the Aberdeen Children of the 1950s), which contain late-life brain MRI scans, childhood and adult cognition, and various other early and late life health-related and socioeconomic variables. In addition, she will give an overview of her group's research directions, and some of the computational techniques employed to investigate healthy brain ageing. Finally, she will discuss her work on the klotho (or longevity) gene, and her research on brain entropy, a possible measure of brain complexity extracted from MRI derived brain activations.