Dr. Suchi Smita

To evaluate the toxicity of mixture of chemicals from combustion aerosols, I am developing computational methods that integrate chemometric and multiomics data using structural biology, chemoinformatics and network inference approaches.

Research interest

"I am interested in multi-omics data integration and analysis and my research activities include biological data analysis and interpretation, molecular docking and molecular dynamics simulations along with statistical analysis."

Currently I am working on HICE (Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health) project where multiomics data is being generated from the lung cells exposed to various aerosols from ship diesel and wood combustion. Detail chemometric data is also being generated from the exposure aerosol.

I am specifically working on the biological targets of various chemical entities present in the aerosols. The work involves development of computational methodologies to integrate chemometirc aerosol data with multi-omics exposure data for predicting potential biomarkers for health effects cause by aerosols.

Academic background

2008 - 2012 Ph.D. (Bioinformatics)
Thesis title: "Identification of suitable target for GsMTx-4, a Venom peptide from Tarantula for the treatment of High Blood Pressure"
2003 - 2005

M. Sc. (Bioinformatics)
Allahabad Agriculture Institute -Deemed University Allahabad, India

2000 - 2003

B.Sc. (Chemistry, Botany, Zoology)
Awadh University, Faizabad India

1997 - 2000

Intermediate (Science)
Central Board of Secondary Education, New Delhi India

1995 - 1997

High School (Science)
Central Board of Secondary Education, New Delhi India

 

Selected publications

Deciphering hallmark processes of aging from interaction networks

Smita S, Lange F, Wolkenhauer O, Köhling R

Biochim Biophys Acta. 2016; S0304-4165(16)30264-1.

Computational analysis and modeling the effectiveness of "Zanamivir" targeting neuraminidase protein in pandemic H1N1 strains

Gupta SK, Gupta SK, Smita S, Srivastava M, Lai X, Schmitz U, Rahman Q, Wolkenhauer O, Vera J (2011)

Infection, Genetics and Evolution 11: 1072 - 1082

Identification of immunogenic consensus T-cell epitopes in globally distributed influenza-A H1N1 neuraminidase

Gupta SK, Srivastava M, Akhoon BA, Smita S, Schmitz U, Wolkenhauer O, Vera J, Gupta SK (2011)

Infection, Genetics and Evolution 11: 308 - 319

Geraniol and limonene interaction with 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase for their role as cancer chemo-preventive agents

Pattanayak M, Seth PK, Smita S, Gupta SK (2009)

Journal of Proteomics & Bioinformatics 2: 466-474

Enriching biotechnology with recent bioinformatics tools and protocols

Gupta SK, Smita S, Rahman Q

in: Recent trends in Biotechnology; Singh MP, Agrawal A, Sharma B (eds.); Nova Science Publishers Inc. 2011.

ISBN 13 (print): 9781608761487

Education and Work Experience

  • Wissenschaftliche Mitarbeiterin  in Comprehensive Molecular Analytics, Helmholtz Zentrum München
  • Post-doctoral Fellow Oscar Langendorff Institute für Physiologie der Universitätsmedizin, Rostock
  • Post-doctoral Fellow at Department of Systems Biology and Bioinformatics, Rostock, Germany