Andrea Bagnacani

I curate large datasets and implement computational pipelines for data annotation, contextualization, and reuse, providing a mean to go from data to information.

Research interest

I provide computational tools to researchers.

I'm a member of the de.STAIR project, which maintains and develops tools for RNA-Seq analysis within the Galaxy framework. My work aims at creating a recommendation system for data analysis tools within Galaxy, leveraging on tool annotations and shared best practices. de.STAIR is a member of the RNA Bioinformatics Center (RBC) within the German Network for Bioinformatic Infrastructure (de.NBI): the ELIXIR node Germany.

I'm working on the TriplexRNA: a database of cooperative microRNAs and their mutual targets. The database contains human and mouse RNA triplexes: a regulatory pattern composed of a siynergistic miRNA pair regulating a target mRNA, which can be used as a biological marker for disease diagnosis. Here, I'm involved in the extension and redesign of the computational pipeline used to compute and organize predicted RNA triplexes for multiple organisms.

I'm a trainer for the Galaxy framework, on the topics of usage, data preprocessing, and visualization.

Projects

Research Projects

GB-XMap: Assessing the risk of gut-brain cross-diseases

Investigating the gut-brain-axis

The gut–brain axis (GBA) provides a bidirectional homeostatic communication between the gastrointestinal tract and the central nervous system. The interdisciplinary collaboration is going to fully explore a first comprehensive GBA cross-disease map of genetic, expression and regulatory changes associated with ulcerative colitis and schizophrenia disease entities.

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de.STAIR: Structured Analysis and Integration of RNA-Seq Experiments

RNA sequencing (RNA-Seq) has become a widely used tool to study quantitative and qualitative aspects of the transcriptome. The variety of RNA-Seq protocols, experimental study designs and the characteristic properties of the organisms under investigation greatly affect downstream and comparative analyses. Our aim is to enable a comprehensive analysis of RNA-Seq experiments as a service. To enable maximum usefulness, interconnectivity, and accessibility for the developed approaches and services, we will provide dedicated workshops, training programs and screen casts for bioinformaticians and other life scientists and, ultimately, lower the barriers to RNA-Seq data analysis as a whole.

 

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Academic background

2017

Galaxy workshop on HTS data analysis, University of Freiburg, Germany

2016

Workshop on Computational Life Sciences, Bayer Pharma AG Berlin, Germany

2016

IDaMo Summer School on the Integration of Data and Models in Medicine

2016

SEMS Hackathon on Model statistics, University of Rostock, Germany

2015

16th Bioinformatics Winter School, University of Bologna, Italy

2014

Contribution to the Semantic Lancet Project, University of Bologna, Italy

2013

EuroPython 2013, Florence, Italy

2011

XML Summer School, St. Edmund Hall, Oxford, UK

2011

Workshop on markup and its semantics, University of Bologna, Italy

 

Selected publications

Evolution of computational models in BioModels Database and the Physiome Model Repository

Scharm M, Gebhardt T, Touré V, Bagnacani A, Salehzadeh-Yazdi A, Wolkenhauer O, Waltemath D

BMC Systems Biology 12:53 (2018)

Robust Cross-Platform Workflows: How Technical and Scientific Communities Collaborate to Develop, Test and Share Best Practices for Data Analysis

Möller S, ..., Bagnacani A, ..., Crusoe MR

Springer Data Science and Engineering

Customized workflow development and data modularization concepts for RNA-Sequencing and metatranscriptome experiments

Lott SC, Wolfien M, Riege K, Bagnacani A, Wolkenhauer O, Hoffmann S, Hess WR

Journal of Biotechnology

The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy

Gruening BA, Fallmann J, Yusuf D, Will S, Erxleben A, Eggenhofer F, Houwaart T, Batut B, Videm P, Bagnacani A, Wolfien M, Lott SC, Hoogstrate Y, Hess WR, Wolkenhauer O, Hoffmann S, Akalin A, Ohler U, Stadler PF, Backofen R

Nucleic Acids Research

Education and Work Experience

present PhD student in Systems Biology and Bioinformatics, University of Rostock, Germany
2016

Master with honours in Bioinformatics, University of Bologna, Italy

2014

Bachelor in Computer Science, University of Bologna, Italy

 

Services