Optimal sampling time selection for parameter estimation in dynamic pathway modeling

This page contains material related to the paper:

Kutalik K, Cho KH, Wolkenhauer O
Optimal sampling time selection for parameter estimation in dynamic pathway modeling
BioSystems 75, pp. 43-55, 2004; DOI:10.1016/j.biosystems.2004.03.007; PMID: 15245803

Main Matlab M-files

simulation.m
Simulates the data sets for ms2RK45.m
ms2RK45.m
Multiple shooting with Runge-Kutta45
zeq.m
Defines the differential equations

Additional Matlab M-files

design1.m
Initialises the design: computes the covariance matrix of the noise in case of equidistant time point selection.
design2.m
Computes the optimal sampling time selection with Powell's quadratic convergent method

Info: Matlab-files are developed in Matlab 7