Dept. of Systems Biology and Bioinformatics is a part of the University of Rostock, Germany Universität Rostock

Felix Winter

Image: Felix Winter

Current Projects

Mathematical modeling of transport process at the blood brain barrier
Alzheimer
Aβ aggregation inside the brain is one major aspect of Alzheimer's disease. The appearance of Aβ plaques is highly correlated with the decline of brain activity. It is therefore necessary to understand the mechanisms regulating Aβ production, Aβ degradation and removal from the brain. The aim of the project is to develop an integrated model to understand the dynamics of Aβ aggregation and its transport through the blood brain barrier.
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Research Interest

In-vivo regulation of Aβ abundance / Energy-metabolism and brain imaging in AD
"I am interested in the aethiopathology of the Alzheimer's disease."

Protein aggregation is a major hallmark of many neurodegenerative diseases. In Alzheimer's disease (AD) the deposition of the protein Amyloid-β (Aβ) is increased and its aggregation leads to cognitive impairment. The question we focus on is: Which mechanisms govern the production and degradation of Aβ inside the brain? How can these mechanisms be influenced to impede or delay disease progression? Which of these mechanisms can be attributed to the process of aging?
Neurodegenerative diseases like AD mostly occur at older ages. If it is possible to understand the underlying mechanisms, this may shed light on the question "What does `getting old` mean in a biological sense?".
We established a mathematical model to capture the in vivo dynamics of Aβ aggregation in mouse-models relating to the regulation of different transmembrane transport proteins. Based on this model the influence on different strategies of altering the Aβ; abundance on AD initiation can be examined. Once the key features of AD progression are worked out we will analyse their relation to aging.
Understanding the aethiopoathology of Alzheimer's disease and working out the inherent connection to the process of aging observed in biological organisms promises insights important for both basic aging research and questions specific for the treatment of the Alzheimer's disease.

Academic Background

2013 - present
Researcher at ASD GmbH in the VPH Dare@IT project.
2009 - present
PhD-Student in Systems Biology, funded by the Faculty of Interdisciplinary Research, Department Aging Sciences and Humanities
University of Rostock, Rostock/Germany
2001 - 2009
Diplom in Business Mathematics (Dipl. Math. oec., comparable to a masters degree)
University of Rostock, Rostock/Germany

Publications

Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Bräunung T, Plath A S, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker L C, Pahnke J (2011)
Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice

Journal of Clinical Investigation 121: 3924-3931
access

Rateitschak K, Winter F, Lange F, Jaster R, Wolkenhauer O (2012)
Parameter Identifiability and Sensitivity Analysis Predict Targets for Enhancement of STAT1 Activity in Pancreatic Cancer and Stellate Cells

PLoS Computational Biology 8: e1002815
open access

D Waltemath, R Henkel, F Winter, O Wolkenhauer
Reproducibility of model-based results in systems biology

In: Systems Biology: Integrative Biology and Simulation Tools 1, pp 301-320. Prokop A, Csukas B (eds) Springer (2013)
DOI: 10.1007/978-94-007-6803-1_10
URL: http://link.springer.com/chapter/10.1007/978-94-007-6803-1_10

Schmitz U, Lai X, Winter F, Wolkenhauer O, Vera J, Gupta S
Cooperative gene regulation by microRNA pairs and their identification using a computational workflow

Nucleic Acid Research 2014, 42 (12): 7539-7552, doi: 10.1093/nar/gku465.
open access

Wolkenhauer O, Auffray C, Brass O, Clairambault J, Deutsch A, Drasdo D, Gervasio F, Preziosi L, et al.
Enabling multiscale modeling in systems medicine

Genome Medicine 2014, 6:21

access

Winter F, Bludszuweit-Philipp C, Wolkenhauer O
Mathematical analysis of the influence of brain metabolism on the BOLD signal in Alzheimer’s disease

Journal of Cerebral Blood Flow & Metabolism
doi: 10.1177/0271678X17693024

Contact Details

Systems Biology and Bioinformatics
Ulmenstrasse 69 (building 3, 3rd floor)
18057 Rostock, Germany
Room 412

phone: +49 381 498-7680
fax: +49 381 498-7572
mail: felix.winter(at)uni-rostock.de

ORCID: 0000-0003-2987-6797

Collaborators & Partners

Prof. Jens Pahnke
Neurodegeneration Research Laboratory Department of Neurology
University of Rostock
University of Rostock
Rostock/Germany
Medical Faculty
University of Rostock, Rostock/Germany
ASD Advanced Simulation and Design GmbH
Rostock / Germany