Dr. Sonja Strunz

I am interested in analyzing radiation-induced changes in transcriptional responses and in biomarker discovery for radiation dose prediction.

Research interest

Bioinformatic analysis in the field of radiation biodosimetry

"I am interested in analyzing radiation-induced changes in transcriptional responses and in biomarker discovery for radiation dose prediction."

Protection of humans from the adverse effects of ionizing radiation is a major goal of radiation biodosimetry. In the case of accidental exposures to radiation the development of effective counter measures requires information on the actual exposure dose. Gene expression analysis is a promising approach to predict the radiation dose in a fast and accurate manner.

The questions we focused on is: What are the transcriptional changes in consequence of ionizing radiation and is it possible to accurately predict the radiation dose of irradiated blood based on transcriptome analysis?

Ionizing radiation is known to function as a carcinogen, but also plays a major role in cancer therapeutics in the field of radiation therapy. On the transcriptional level ionizing radiation initiates a complex series of expression alterations, which are dependent upon genetic background, dose, dose-rate, and time after irradiation. A better understanding of individual radiation-induced cellular processes may help us to develop optimized therapy protocols or to stem long-term effects of ionizing radiation.

We identified genes showing a radiation-induced and dose-dependent expression status, most of them functionally linked to radiation related biological processes (i.e. apoptosis, DNA-damage or cell-cycle regulation). Furthermore, we established p-value and fold-change-driven prediction framework to extract small gene expression signatures which are particularly suitable for dose estimation.

The genes identified are potential robust biomarkers, which are particularly suitable for dose level discrimination at a window of time that would be appropriate for life-saving medical triage.

Academic background

2007 - 2014 Doctorate Degree in Computer Science
University of Rostock, Rostock/Germany
2000 - 2007 Masters Degree in Bioinformatics (Dipl. Bioinformatiker)
University of T

 

Selected publications

Gene expression in low and high dose-irradiated human peripheral blood lymphocytes: Possible applications for biodosimetry

Knops K, Boldt S, Wolkenhauer O, Kriehuber R (2012)

Radiation Research 178:304-312

A Frequency Based Gene Selection Method to Identify Robust Biomarkers for Radiation Dose Prediction

Boldt S, Knops K, Kriehuber R, Wolkenhauer O (2012)

International Journal of Radiation Biology 3:267-276

The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

Schult C, Dahlhaus M, Ruck S, Sawitzky M, Amoroso F, Lange S, Etro D, Glass A, Fuellen G, Boldt S, Wolkenhauer O, Neri LM, Freund M, Junghanss C (2010)

BMC Cancer 10: 560

Network-Assisted Disease Classification and Biomarker Discovery

S. Strunz, O. Wolkenhauer, A. de la Fuente

In Springer (2016), Systems Medicine, pp 353-374

ISBN 13 (print): 9781493932825

ISBN 13 (online): 9781493932832

URL: http://link.springer.com/protocol/10.1007/978-1-4939-3283-2_16

Reverse Engineering of Biological Networks

Assmus HE, Boldt S, Wolkenhauer O

in: Methods in Bioengineering: Systems Analysis of Biological Networks; Jayaraman A, Hahn J (eds.); Artech House 2009.

ISBN 13 (print): 9781596934061

BIB: Download file

Identification of gene-based biosignatures for radiation biodosimetry

Boldt S, Knops K, Kriehuber R, Wolkenhauer O

58. Biometrisches Kolloquium, Berlin, Germany, March 2012

Venue: Berlin, Germany

Identification of radiation-specific gene expression changes in human PBL after ex vivo irradiation suitable for biodosimetric applications

Knops K, Boldt S, Wolkenhauer O, Kriehuber R

14th International Congress of Radiation Research, Warsaw, Poland, August 2011

Venue: Warsaw, Poland

Gene expression analysis in Jurkat cells after exposure to I-123-iododeoxyuridine, Gamma-rays and Alpha-particles

Unverricht-Yeboah M, Boldt S , Giesen U, Pomplun E, Wolkenhauer O, Kriehuber R

14th International Congress of Radiation Research, Warsaw, Poland, August 2011

Venue: Warsaw, Poland

A p-value and fold-change driven gene selection method for radiation dose prediction

Boldt S, Knops K, Kriehuber R, Wolkenhauer O

EPRBioDose, Mandelieu-La-Napoule, France, October 2010

Venue: Mandelieu-La-Napoule, France

Gene expression pattern analysis in human PBLs as a tool for radiation biodosimetry

Knops K, Boldt S, Wolkenhauer O, Kriehuber R

EPRBioDose, Mandelieu-La-Napoule, France, October 2010

Venue: Mandelieu-La-Napoule, France

Radiation responsive genes in human lymphocytes as a tool for radiation biodosimetry

Knops K, Boldt S, Wolkenhauer O, Kriehuber R

GBS Tagung, Hamburg, Germany, September 2010

Venue: Hamburg, Germany

A Data Analysis Workflow for the Identification of Expression Signatures Functioning as Molecular Biodosimeters

Boldt S, Knops K, Kriehuber R, Wolkenhauer O

German Conference of Bioinformatics, Halle (Saale), Germany, September 2009

Venue: Halle (Saale), Germany

Gene Expression pattern analysis as a tool for radiation biodosimetry

Knops K, Boldt S, Wolkenhauer O, Kriehuber R

ERRS, Prague, Czech Republic, August 2009

Venue: Prague, Czech Republic

Detecting Differential Gene Expression in ALL Cell Lines Treated with the Multikinase Inhibitor Sorafenib

Boldt, Glass, Schult, Junghanß, Wolkenhauer

Systems Biology for Medical Applications, Summer School, Costa Adeje, Soain, 30 October 2008

Venue: Costa Adeje, Soain

Sorafenib inhibits proliferation in B- and T- Lymphoblastic cell lines via the PI3k/AKT Pathway

Schult C, Dahlhaus M, Glass A, Boldt S, Ruck S, Sawitzky M, Lange M, Amoroso F, Freund M, Neri L, Junghanss C

Ash, San Francisco, USA, 2008

Venue: San Francisco, USA

Transcriptional Responses to Radiation Exposure Facilitate the Discovery of Biomarkers Functioning as Radiation Biodosimeters

Strunz S

2014