Sherry Freiesleben

To uncover aberrant molecular mechanisms behind diseases such as multiple sclerosis or radiation sickness, I study gene expression, transcription factors, microRNAs and lncRNAs to construct regulatory networks which I then explore

Research interest

microRNAs and data integration - Why should we even bother?

microRNAs (miRNAs) are non-coding RNAs that post-transcriptionally regulate gene expression. They partake in diverse biological processes and have been reported to be involved in many diseases. Their expression profiles can easily be investigated since they are present in a stable form in human blood and plasma.

Therefore, what role do these tiny molecules play in the development of diseases?

To answer this question, I first analyze transcriptomics data in order to identify candidate miRNAs and genes. I then make use of data originating from various databases and of data integration methods to generate regulatory networks. After constructing these networks, I apply network analysis methods such as to uncover regulatory interactions involving miRNAs which may help us better understand the role of these molecules in diseases.

Academic background

2011 -present

PhD: Bioinformatics
University of Rostock, Rostock, Germany

2009 - 2011

Master of Science: Medical Biotechnology
University of Rostock, Rostock, Germany

2009 - 2006

Bachelor of Science: Major Physiology, Minor Physics
McGill University, Montreal, Canada

Summer Semester 2006

Guest Student: Physics
University of Rostock, Rostock, Germany

2003 - 2005

Diploma of College Studies: Health Science
Vanier College, Montreal, Canada


Selected publications

A workflow for the creation of regulatory networks integrating miRNAs and lncRNAs associated with exposure to ionizing radiation using open source data and tools

Freiesleben S, Unverricht-Yeboah M, Gütebier L, Waltemath D, Kriehuber R, Wolkenhauer O

accepted for publication in Frontiers in Systems Biology

Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study.

Singh N, Freiesleben S, Wolkenhauer O, Shukla Y, Gupta SK

Curr Pharm Des. 2017;23(32):4773-4793.

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

Sherry Freiesleben, Michael Hecker, Uwe Klaus Zettl, Georg Fuellen, Leila Taher

Scientific Reports (2016) 6: 34512

Investigation of mammalian microRNA biogenesis by use of mathematical modeling

Freiesleben S