Sherry Freiesleben

To uncover interactions that lead to aberrant molecular mechanisms behind ailments such as multiple sclerosis or radiation sickness, I study gene expression, transcription factors and microRNAs to construct regulatory networks which I then explore.

Research interest

microRNAs and data integration - Why should we even bother?

microRNAs (miRNAs) are non-coding RNAs that post-transcriptionally regulate gene expression. They partake in diverse biological processes and have been reported to be involved in many diseases. Their expression profiles can easily be investigated since they are present in a stable form in human blood and plasma.

Therefore, what role do these tiny molecules play in the development of diseases?

To answer this question, I first analyze transcriptomics data in order to identify candidate miRNAs and genes. I then make use of data originating from various databases and of data integration methods to generate regulatory networks. After constructing these networks, I apply network analysis methods such as to uncover regulatory interactions involving miRNAs which may help us better understand the role of these molecules in diseases.

Projects

Research Projects

Complex DNA lesions and their impact on cellular radiation response - Collar

The investigations will deepen our knowledge on the impact of radiation-induced complex DNA lesions with spinoffs for radiation protection and the development of new, advanced tumor therapy strategies.

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Academic background

2011 - present

PhD: Medical Bioinformatics
University of Rostock, Rostock, Germany

2009 - 2011

Master of Science: Medical Biotechnology
University of Rostock, Rostock, Germany

2009 - 2006

Bachelor of Science: Major Physiology, Minor Physics
McGill University, Montreal, Canada

Summer Semester 2006

Guest Student: Physics
University of Rostock, Rostock, Germany

2003 - 2005

Diploma of College Studies: Health Science
Vanier College, Montreal, Canada

 

Selected publications

Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study.

Singh N, Freiesleben S, Wolkenhauer O, Shukla Y, Gupta SK

Curr Pharm Des. 2017;23(32):4773-4793.

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

Sherry Freiesleben, Michael Hecker, Uwe Klaus Zettl, Georg Fuellen, Leila Tahera

Scientific Reports (2016) 6: 34512

Investigation of mammalian microRNA biogenesis by use of mathematical modeling

Freiesleben S

2011