Paulina Christen

Research interest

Medical biotechnology student with a  strong interest in bioinformatics and disease mechanism modeling. Motivated to gain hands-on experience as a student research assistant in disease map building project, with the goal of expanding this work in my upcoming Master’s thesis. Very enthusiastic about learning new computational tools and techniques for integrating and analyzing biological interaction data.

Projects

Research Projects

AKOP: Atlas of Knee Osteoarthritis and Pain Signaling

AKOP (Atlas of Knee Osteoarthritis & Pain Signaling) is an interactive systems biology resource that links molecular mechanisms of knee osteoarthritis with pain-related signaling pathways in a unified disease map. By integrating curated knowledge on inflammation, tissue remodeling, cellular communication, and pain processes, AKOP enables researchers to explore KOA as a complex, multi-tissue disease rather than as an isolated cartilage disorder. Hosted on the MINERVA platform, the atlas supports data overlay, visual analytics, and hypothesis generation, thereby providing a foundation for mechanistic interpretation of omics and imaging data, biomarker discovery, and future patient stratification approaches.

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APM: The Atlas of Pain Mechanisms
The Atlas of Pain Mechanisms (APM) is an interactive, multi-layered network-based pain resource that connects molecular mechanisms of pain signalling with clinical pain phenotypes across biological scales. Combining manually curated pathway maps with embedded clinical assessment tools and deployed on the MINERVA platform, APM provides a computable resource for the mechanistic exploration of pain in inflammatory disease, with knee osteoarthritis as the first use case.
 

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Selected publications

Education and Work Experience

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