Dr. Katja Rateitschak

Postdocs (from 2004-01-01 until 2014-04-14)
Scientific employee

Research interest

We combine theoretical and experimental systems biology to challenge pancreatic cancer in the project of my junior research group. It focuses on mathematical modelling of chemical kinetics and transport processes in biochemical reaction networks of pancreatic cancer cells.

By an iterative cycle of quantitative cell biology, mathematical modelling, parameter estimation and identifiability analysis, study of transient dynamics and sensitivity analysis, design of refined experiments and experimental validation of model predictions we want to understand, predict and improve the cellular response to chemotherapy. This project is done in collaboration with Prof. R. Jaster (Department of Gastroenterology, Medical Faculty University of Rostock).

I am also involved in other projects where we study neurodegenerative diseases by a systems biology approach.The mathematical modelling of biochemical networks is accomplished by the development of mathematical tools to analyze transient signalling and to improve the experimental design.

Academic background

2013 - 2014

Scientific employee, Systems Medicine Initiative, Department of Systems Biology and Bioinformatics and Institute for Biostatistics and Informatics in Medicine
University of Rostock, Rostock/Germany

2008 - 2013

FORSYS junior research group leader, Systems Biology and Bioinformatics
University of Rostock, Rostock/Germany

2004 - 2008

Postdoc, Systems Biology and Bioinformatics
University of Rostock, Rostock/Germany

2001 - 2004

Postdoc at Max Planck Institutes in Berlin and Potsdam

1996 - 2001

Docteur en Science, Center for Nonlinear Phenomena and Complex Systems
University

Selected publications

Autocrine TGF-beta/ZEB/microRNA-200 signal transduction drives epithelial-mesenchymal transition: Kinetic models predict minimal drug dose to inhibit metastasis

Katja Rateitschak, Lars Kaderali, Olaf Wolkenhauer, Robert Jaster (2016)

Cellular Signalling

Anti-inflammatory effects of reactive oxygen species – a multi-valued logical model validated by formal concept analysis

Wollbold J, Jaster R, Müller S, Rateitschak K, Wolkenhauer O

BMC Systems Biology, 8:101

Enabling multiscale modeling in systems medicine

Wolkenhauer O, Auffray C, Brass O, Clairambault J, Deutsch A, Drasdo D, Gervasio F, Preziosi L, et al.

Genome Medicine 2014, 6:21

Analysing the impact of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists APC, Axin and GSK3 on Wnt/beta-catenin signalling

Schmitz Y, Rateitschak K, Wolkenhauer O (2013)

Cellular Signalling, 2210:2221

An explicit numerical scheme to efficiently simulate molecular diffusion in environments with dynamically changing barriers

Kossow C, Rybacki S, Millat T, Rateitschak K, Jaster R, Uhrmacher AM, Wolkenhauer O (2015)

Mathematical and Computer Modelling of Dynamical Systems.

Parameter Identifiability and Sensitivity Analysis Predict Targets for Enhancement of STAT1 Activity in Pancreatic Cancer and Stellate Cells

Rateitschak K, Winter F, Lange F, Jaster R, Wolkenhauer O (2012)

PLOS Computational Biology 8: e1002815

Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach

Lange F, Rateitschak K, Kossow C, Wolkenhauer O, Jaster R (2012)

World Journal of Gastroenterology 18: 6226-6234

Mathematical modelling unravels regulatory mechanisms of interferon-?-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells

Kossow C, Jose D, Jaster R, Wolkenhauer O, Rateitschak K (2012)

IET System Biology 6: 73-85

Quantitative modeling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, Wiesner B, Petersen CM, Nykjaer A, Wolf J, Wolkenhauer O, Willnow T (2012)

EMBO Journal 31: 187-200

Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice

Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Bräunung T, Plath A S, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker L C, Pahnke J (2011)

Journal of Clinical Investigation 121: 3924-3931

Systems Biology Of JAK-STAT Signalling In Human Malignancies

Vera J, Rateitschak K, Lange F, Kossow C, Wolkenhauer O, Jaster R (2011)

Progress in Biophysics and Molecular Biology 106: 426-434

Nucleo-cytoplasmic shuttling of APC can maximize beta-catenin/TCF concentration

Schmitz Y, Wolkenhauer O, Rateitschak K (2011)

Journal of Theoretical Biology 279: 132-142

Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach

Lange F, Rateitschak K, Fitzner B, Pohland R, Wolkenhauer O and Jaster R (2011)

Molecular Cancer 10: 13

Thresholds in transient dynamics of signal transduction pathways

Rateitschak K, Wolkenhauer O (2010)

Journal of Theoretical Biology 264: 334 - 346

Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts dynamics of STAT1 pathway activity

Rateitschak K, Karger A, Fitzner B, Lange F, Wolkenhauer O, Jaster R (2010)

Cellular Signalling 22: 97-105

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs

Wolkenhauer O, Rateitschak K, Auffray Ch, Baltrusch S, Blüthgen N, Byrne H et al. (2009)

Cancer Research 70: 12-3

Intracellular delay limits cyclic changes in gene expression

Rateitschak K, Wolkenhauer O (2007)

Mathematical Biosciences 205: 163-79

Wnt signal pathways and neural stem cell differentiation

Lange C, Mix E, Rateitschak K, Rolfs A (2006)

Neurodegenerative Dis. 3: 76-86

Interferon-g stimulated STAT1 signalling: from experimental data to a predictive mathematical model

Rateitschak K, Jaster R, Wolkenhauer O

in: Proceedings of the 4th International Beilstein Symposium on Experimental Standard Conditions of Enzyme Characterizations; Hicks MG , Kettner C (eds.); Logos Berlin 2010.

ISBN 13 (print): 9783832526067

Bifurcation threshold in the MAPK cascade is independent of the Hill coefficient

Rateitschak K, Kschischo M

in: Irreversible Prozesse und Selbstorganisation; Pöschel ET, Malchow H, Schimansky-Geier L (eds.); Logos Verlag Berlin 2006.

ISBN 13 (print): 9783832513504

BIB: Download file

Continuous states on a grid enable an efficient simulation of diffusion in environments with excluded volumes

Kossow C, Rybacki S, Millat T, Rateitschak K, Uhrmacher AM, Wolkenhauer O

Biotec Forum ''Bioinformatics and Computational Biology'', Dresden, Germany, 06 December - 07 December 2012

Venue: Dresden, Germany

Mathematical modelling points out regulatory mechanisms of interferon-gamma induced STAT1 serine phosphorylation and MUC4 expression in pancreatic cancer cells

Kossow C, Jose D, Jaster R, Wolkenhauer O, Rateitschak K

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

Mathematical modelin of protein aggregation and transport in Alzheimer's disease

Winter F, Krohn M, Lange C, Pahnke J, Wolkenhauer O, Rateitschak K

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

Mathematical Modeling of APP Processing influenced by SORLA in Alzheimers Disease

Lao A, Schmitz Y, Schmidt V, Rateitschak K, Wolf J, Willnow T, Wolkenhauer O

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

Mathematical modelling of the Wnt pathway: the influence of nucleo-cytoplasmic shuttling of beta-catenin and its antagonists APC, Axin and GSK3

Schmitz Y, Rateitschak K, Wolkenhauer O

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

Mathematical modelling of nucleo-cytoplasmic shuttling of beta-catenin and its antagonist APC

Schmitz Y, Wolkenhauer O, Rateitschak K

11th International Conference on Systems Biology (ICSB), Edinburgh, UK, 10-15 October 2010

Venue: Edinburgh, UK

Interferon gamma stimulated STAT1 signalling in pancreatic stellate cells: From experimental data to mathematical models, Workshop "Modelling in BioMedicine"

Rateitschak K, Lange F, Fitzner B, Wolkenhauer O, Jaster R

11th International Conference on Systems Biology, Edinburgh, UK, 10.10.-15.10.2010

Venue: Edinburgh, UK

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Schmidt V, Lao A, Rateitschak K, Wolkenhauer O, Willnow T

Honolulu, Hawaii, 10.07-15.07.2010

Venue: Honolulu, Hawaii

Quantitative analysis of the SNF1-pathway in Saccharomyces cerevisiae

Garcia-Salcedo R, Frey S, Beltran G, Bosch D, Elbing K, Tian Y, Manchala S, Rateitschak K, Wolkenhauer O, Hohmann S

35thFEBS Congress 2010, Göteborg (Gothenburg), Sweden. June 26 - July 1, 2010

Venue: Gothenburg, Sweden

Quantitative analysis of the SNF1-pathway in Saccharomyces cerevisiae

Garcia-Salcedo R, Frey S, Beltran G, Bosch D, Elbing K, Tian Y, Manchala S, Rateitschak K, Wolkenhauer O, Hohmann S

35thFEBS Congress 2010, Göteborg (Gothenburg), Sweden. June 26 - July 1, 2010

Venue: Gothenburg, Sweden

Interferon gamma stimulated STAT1 signalling in pancreatic stellate cells: From experimental data to mathematical models

Rateitschak K, Lange F, Fitzner B, Wolkenhauer O, Jaster R

Conference on Systems Biology of Mammalian Cells-SBMC2010, Freiburg, Germany, 3-5 June 2010

Venue: Freiburg, Germany

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Lao A, Schmidt V, Rateitschak K, Wolkenhauer O, Willnow T

Mid-term review of the Helmholtz Alliance on Systems Biology, DKFZ, Heidelberg, Germany, 13.01.-14.01.2010

Venue: Heidelberg, Germany

Charakterisierung intrazellulärer Signalwege in pankreatischen Sternzellen mit Hilfe mathematischer Modellierung

Lange F, Fitzner B, Jaster R, Karger A, Wolkenhauer O, Rateitschak K

30. Jahrestagung des Deutschen Pankreasclub, Heidelberg, Germany, November 2009

Venue: Heidelberg, Germany

Protein networks controlling amyloidogenic processing

Willnow T, Schmidt V, Lao A, Rateitschak K, Wolkenhauer O

Second status seminar and meeting of the advisory board of the Helmholtz Alliance on Systems Biology, DKFZ, Heidelberg, Germany, 26.10.-27.10.2009

Venue: Heidelberg, Germany

Interferon gamma stimulated Stat1 signaling pathway in pancreatic stellate cells: From experimental data to mathematical models

Rateitschak K, Karger A, Fitzner B, Lange F, Wolkenhauer O, Jaster R

4. ESCEC Symposium, Rüdesheim, Germany, 09.2009

Venue: Rüdesheim, Germany

Interferon gamma stimulated Stat1 signaling pathway in pancreatic stellate cells: From experimental data to mathematical models

Rateitschak K, Karger A, Fitzner B, Lange F, Wolkenhauer O, Jaster R

Transatlantic Summer School Cancer Systems Biology, Rostock, Germany, June 2009

Venue: Rostock, Germany

Interferon gamma stimulated Stat1 signaling pathway in pancreatic stellate cells: From experimental data to mathematical models

Rateitschak K, Karger A, Fitzner B, Lange F, Wolkenhauer O, Jaster R

German Symposium on Systems Biology, Heidelberg, Germany, May 2009

Venue: Heidelberg, Germany

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Lao A, Schmidt V, Rateitschak K, Willnow T, Wolkenhauer O

Spring school 2009 on Systems Biology, Kloster Seeon, Germany, 06.04.-09.04.2009

Venue: Kloster Seeon, Germany

Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin antagonists by mathematical modelling

Schmitz Y, Bader BM, Weiss DG, Wolkenhauer O, Rateitschak K

Summer School on Systems Biology for Medical Applications, Tenerife, Spain, 30.09.-02.10.2008

Venue: Tenerife, Spain

Threshold properties of Interferon-gamma stimulated Jak2-Stat1 signaling in pancreatic stellate cells: From experimental data to mathematical models

Karger A, Rateitschak K, Fitzner B, Wolkenhauer O, Jaster R

2nd International workshop on systems biology, Hamilton, Ireland, August 2008

Venue: Hamilton, Ireland

A power-law model to describe the aggregation of Beta-Amyloid and its transport across the Blood-Brain barrier based on quantitative data from Alzheimer mouse models

Winter F, Krohn M, Lange C, Wolkenhauer O, Rateitschak K, Pahnke J

2nd International workshop on systems biology, Hamilton, Ireland, August 2008

Venue: Hamilton, Ireland

Modelling Snf1 regulation in Saccharomyces cerevisiae

Frey S, Schmidt H, Rateitschak K, Beltran G, Garcia-Salcedo R, Elbing K, Bosch D, Ye T, Hohmann S, Wolkenhauer O

9th International Conference on Systems Biology, Göteborg (Gothenburg), Sweden, August 2008

Venue: Gothenburg, Sweden

Quantitative 3D image analysis to study the beta-catenin translocation during differentiation of human neural progenitor cells

Bader BM, Schmitz Y, Redlich B, Rateitschak K, Wolkenhauer O, Weiss DG

2nd International Congress on Stem Cells and Tissue Formation, Dresden, Germany, July 2008

Venue: Dresden, Germany

Mathematical modeling of neurodegenerative processes in alzheimer's diesease

Rateitschak K, Schmidt V, Carlo AS, Sporbertm A, Lao A, Wolkenhauer O, Willnow T

First status seminar of the Helmholtz alliance on systems biology. Potsdam, Germany, June 2008

Venue: Potsdam, Germany

Nonlinear dynamics of biochemical networks in pancreatic cancer: From experimental data to mathematical models

Rateitschak K, Karger A, Fitzner B, Wolkenhauer O, Jaster R

First FORSYS symposium. Berlin, Germany, June 2008

Venue: Berlin, Germany

Thresholds in transient dynamics of signal transduction pathways

Rateitschak K, Wolkenhauer O

Cancer workshop, University of Nottingham, Nottingham, UK, January 2008

Venue: Nottingham, UK

Thresholds in transient dynamics of signal transduction pathways

Rateitschak K, Wolkenhauer O

Joint Receptor Tyrosine Kinase (RTK) Consortium & British Society for Proteome Research/European Bioinformatics Institute Workshop, Hinxton Hall Conference Centre Cambridge, UK, 23-24 July 2007

Venue: Cambridge, UK

Quantitative measures to characterize properties of signal transduction pathways

Frey S, Millat T, Rateitschak K, Wolkenhauer O

Winter Simulation Conference (WSC '06), December 2006

Tresholds in transient dynamics of signal transduction pathways

Rateitschak K, Wolkenhauer O

Proc. ICSB 2006, Yokohama, Japan, 2006

Venue: Yokohama, Japan

Steady state - limit cycle - steady state transitions in gene transcription networks with distributed time delay

Rateitschak K, Wolkenhauer O

International Conference for Systems Biology (ICSB), Boston, USA, October 2005

Venue: Boston, USA,

Systembiologie des kanonischen Wnt-Signalweges

Rateitschak K, Lange C, Mix E, Rolfs A, Wolkenhauer O

LaborPraxis, Vol. 29, 24-26, June 2005