Prof. Mukhtar Ullah

I am interested in cell populations in the stem cell niche.

Postdocs (from 2009-01-01 until 2013-05-13)
Scientific employee

Research interest

Stochastic Dynamics of Stem Cell Populations

"I am interested in cell populations in the stem cell niche."

With their ability to renew and divide into different specialized cell types, stem cells play a key role in the maintenance and repair of adult organisms.

The question we focus on is: How does the proportion of populations of differentiated cells relative to stem cells relates to the functioning of tissue?
Due to intrinsic cell-cell variation and environmental effects, cellular population dynamics have an unavoidable uncertainty (noise). To relate tissue fate to the noisy cell population dynamics, a modelling framework is needed in which biological questions of interest can be cast in terms of probabilities.
Most works in the literature on stem cells either ignore noise completely (by using deterministic approaches) or rely on detailed stochastic simulations of each cell. Our aim is to incorporate noise and yet keep modelling tractable to allow room for intuition.
Methods from large deviation theory will be employed in the Langevin framework so that questions about specific tissue fates can be cast in terms of probabilities of specific trajectories. Traditional approximations based on mean and variance cannot be used because of inherent bistabilities of stem cell populations.

Academic background

2009 - 2013

PostDoc, Systems Biology and Bioinformatics
University of Rostock, Rostock/Germany

2003 - 2009

Doctor of Engineering in Systems Biology, Systems Biology and Bioinformatics
University of Rostock, Rostock/Germany

2001 - 2002

Master of Science in Advanced Control and Systems Engineering
University of Manchester, Manchester/United Kingdom

1994 - 1999

Bachelor of Science in Electrical Engineering
NWFP University of Engineering and Technology Peshawar, Peshawar/Pakistan

Selected publications

Accounting for randomness in measurement and sampling in studying of cancer cell population dynamics

Ghavami S, Wolkenhauer O, Lahouti F, Ullah M, Linnebacher M

IET Systems Biology, 8(5):230-41.

Stochastic approaches in systems biology

Ullah M, Wolkenhauer O (2009)

Wiley Interdisciplinary Reviews: Systems Biology and Medicine 4: 385-397

Investigating the two-moment characterisation of subcellular biochemical networks

Ullah M, Wolkenhauer O (2009)

Journal of Theoretical Biology 3: 340-352

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Family tree of Markov models in systems biology

Ullah M, Wolkenhauer O (2007)

IET Systems Biology 1: 247-254

Deterministic modelling and stochastic simulation of biochemical pathways using MATLAB

Ullah M, Schmidt H, Cho KH, Wolkenhauer O (2006)

IEE Proc Systems Biology 2: 53-60

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A systems- and signal-oriented approach to intracellular dynamics

Wolkenhauer O, Sreenath S, Wellstead P, Ullah M, Cho KH (2005)

Biochemical Society Transactions 3: 507-515

The dynamic systems approach to control and regulation of intracellular networks

Wolkenhauer O, Ullah M, Wellstead P, Cho KH (2005)

FEBS Letters 579: 1846-1853

Modeling and simulation of intracellular dynamics: choosing an appropriate framework

Wolkenhauer O, Ullah M, Kolch W, Cho KH (2004)

IEEE Transactions on NanoBioScience 3: 200-207

Modeling Colorectal Cancer: A Stability Analysis Approach

Nikolow S, Ullah M, Nenov M, Gonzales JV, Raasch P, Wolkenhauer O

in: Medical Advancements in Aging and Regenerative Technologies; Daskalaki A
Clinical Tools and Applications: 53-75
IGI Global 2013

All Models are Wrong

Wolkenhauer O, Ullah M

in: Systems Biology - Philosophical Foundations; Boogard F, Bruggeman F, Hofmeyr J, Westerhoff H (eds.); Elsevier 2006.

ISBN 10 (print): 0444520856

BIB: Download file

The Role of Theory, Modelling and Simulation in Systems Biology

Wolkenhauer O, Ullah M

Towards a Philosophy of Systems Biology, Amsterdam, Netherlands, May 2005

Venue: Amsterdam, Netherlands

The role of feedback in the control and regulation of intracellular networks

Wolkenhauer O, Ullah M

Biochemical Society, Sheffield, UK, January 2005

Venue: Sheffield, UK

Choosing an appropriate modelling framework: How deterministic are random processes?

Ullah M, Cho KH, Kolch W, Wolkenhauer O

International Conference on Systems Biology (ICSB) 2004, Heidelberg, Germany, October 2004

Stochastic Modelling of Subcellular Biochemical Systems

Ullah M

2009