Dr. Angelyn Lao

I am interested in understanding the interactions among SorLA and the proteins in the APP processing through mathematical modelling.

PhD Students (from 2008-01-01 until 2013-12-31)

Thesis title: "A Systems Biology Approach to Understand the Influence of SORLA on Amyloidogenic Processing in Alzheimer's"

Research interest

Mathematical modeling of APP processing influenced by SorLA in Alzheimer‘s disease

"I am interested in understanding the interactions among SorLA and the proteins in the APP processing through mathematical modelling."

The processing of Amyloid Precursor Protein (APP), the central pathology of Alzheimer’s disease, undergoes two pathways: amyloidogenic and non-amyloidogenic. The amyloidogenic pathway produces amyloid beta (Aβ) plaque which is a pathological hallmark of Alzheimer’s disease.
The question we focused on is: How does SorLA, the intracellular sorting receptor, influences the processing of APP in Alzheimer’s disease?
It is important to understand how SorLA interacts with the proteins in the processing of APP that eventually reduces the formation of Aβ plaques in Alzheimer’s disease.
We established the mathematical models (without and with compartment details) describing the biochemical networks, including the interactions among SorLA and the proteins in the processing, regulating the decision process between the two pathways. We analyzed the models based on the experimental dose-response data (APP-sAPPα, sAPPβ, Aβ) we produced using the Tet-off mechanism.
The series of dose-response data show a decreasing effect of SorLA to sAPPα and Aβ, and a surprising minimal effect of SorLA to sAPPβ in the APP processing. Our analyses of the mathematical equations suggest that the “compartment model” matches the profile of the experimental dose-response series data for APP-sAPPα and APP-sAPPβ, and the description of the biological knowledge for Aβ in dependence of APP.

Academic background

2008 - 2013

Doctorate Degree in Computer Science
University of Rostock, Rostock/Germany

2005 - 2013

Doctorate Degree of Science in Mathematics
University of the Philippines Diliman, Quezon City/Philippines

2001 - 2004

Masters Degree of Science in Mathematics
De La Salle University, Manila/ Philippines

1996 - 2000

Bachelor Degree of Science in Mathematics
De La Salle University, Manila/ Philippines

1996 - 2000

Bachelor Degree of Secondary Education in Computer Application
De La Salle University, Manila/ Philippines

Selected publications

Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease

Lao A, Schmidt V, Schmitz Y, Willnow T, Wolkenhauer O (2012)

BMC Systems Biology 6:74

Quantitative modeling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, Wiesner B, Petersen CM, Nykjaer A, Wolf J, Wolkenhauer O, Willnow T (2012)

EMBO Journal 31: 187-200

Regulated Trafficking of APP by SORLA in Alzheimers Disease

Lao A, Schmidt V, Schmitz Y, Willnow T, Wolkenhauer O

Systems Medicine International Conference (SYSMED), Dublin, Ireland, 9 September - 13 September 2012

Venue: Dublin, Ireland

Multi-compartmental modeling of APP processing influenced by SORLA in Alzheimers disease

Lao A, Schmidt V, Schmitz Y, Willnow T, Wolkenhauer O

13th International Conference on Systems Biology (ICSB), Toronto, Canada, 19 August - 23 August 2012

Venue: Toronto, Canada

Mathematical Modeling of APP Processing influenced by SORLA in Alzheimers Disease

Lao A, Schmitz Y, Schmidt V, Rateitschak K, Wolf J, Willnow T, Wolkenhauer O

12th International Conference on Systems Biology (ICSB), Heidelberg/Mannheim, Germany, 28 August - 1 September 2011

Venue: Heidelberg/Mannheim, Germany

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Schmidt V, Lao A, Rateitschak K, Wolkenhauer O, Willnow T

Honolulu, Hawaii, 10.07-15.07.2010

Venue: Honolulu, Hawaii

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Lao A, Schmidt V, Rateitschak K, Wolkenhauer O, Willnow T

Mid-term review of the Helmholtz Alliance on Systems Biology, DKFZ, Heidelberg, Germany, 13.01.-14.01.2010

Venue: Heidelberg, Germany

Protein networks controlling amyloidogenic processing

Willnow T, Schmidt V, Lao A, Rateitschak K, Wolkenhauer O

Second status seminar and meeting of the advisory board of the Helmholtz Alliance on Systems Biology, DKFZ, Heidelberg, Germany, 26.10.-27.10.2009

Venue: Heidelberg, Germany

Systems Approaches in Molecular and Cell Biology: Making Sense out of Data, Providing Meaning to Models

Wolkenhauer O, Lao A, Omholt S, Martens H

Independent Component Analysis, Wavelets, Neural Networks, Biosystems and Nanoengineering VII, Orlando, USA, 13.04.2009

DOI: http://dx.doi.org/10.1117/12.822742

Venue: Orlando, USA

Mathematical modelling of APP processing influenced by SORLA in Alzheimer's disease

Lao A, Schmidt V, Rateitschak K, Willnow T, Wolkenhauer O

Spring school 2009 on Systems Biology, Kloster Seeon, Germany, 06.04.-09.04.2009

Venue: Kloster Seeon, Germany

Mathematical modeling of neurodegenerative processes in alzheimer's diesease

Rateitschak K, Schmidt V, Carlo AS, Sporbertm A, Lao A, Wolkenhauer O, Willnow T

First status seminar of the Helmholtz alliance on systems biology. Potsdam, Germany, June 2008

Venue: Potsdam, Germany

A Systems Biology Approach to Understand the Influence of SORLA on Amyloidogenic Processing in Alzheimer's Disease

Lao A

2013