SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
+49 381 498-7571
A platform for trimming and extracting genome-scale metabolic models (GEMs)
At the most basic abstraction level, biological phenomena can be represented as mathematical graphs. Genome-scale metabolic models (GEMs) are an example, that describe the associations between genes, proteins, and reactions of an organism. Such models are typically encoded as multipartite graphs, which are partitioned into distinct subsets of vertices representing metabolites, reactions, and enzymes. Since topological analyses of large-scale multipartite graphs is challenging, one is often identifying subnetworks from a whole genome metabolic model. Extracting the reaction-centric (links of reactions) or enzyme-centric (links of enzymes) view simplifies the graph structure and shifts its perspective – from kinetic interactions to phenotypical connections. This opens opportunities for novel topological analyses of the metabolism.
In this project, we describe a web-based tool called GEMtractor to trim models encoded in SBML. It can be used to extract subnetworks, focusing on reaction- and enzyme-centric views into the model. The GEMtractor is licensed under the terms of GPLv3 and developed at https://github.com/binfalse/GEMtractor – a public version is available at https://www.sbi.uni-rostock.de/gemtractor.
The GEMtractor comes with an extensive FAQ, proper Python documentation and example client implementations in different programming languages. Automatic tests cover most of its source code to prevent future programming mistakes and the GEMtractor exposes a monitoring endpoint to keep an eye on its health.
The GEMtractor makes it possible to concentrate on less complex views into a model, facilitating the comparison of genome-scale models through topological analysis.
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