iPlacenta: A Systems Biology Approach towards Phenotype-Specific Interactomes for Placental Function

iPlacenta: A Systems Biology Approach towards Phenotype-Specific Interactomes for Placental Function

Pre-eclampsia (PE) is a complex disorder occurring during pregnancy and the postpartum affecting almost 5-8% of all pregnancies and often occurs with other complications. Its pathology is largely unknown. To improve the diagnosis and treatment outcomes, a deeper understanding of the determinants of pathophysiology is urgently needed.

We are developing disease maps of PE and IUGR. We are using open source datasets to create a preliminary disease map, which will be enriched using heterogeneous data generated within the consortium. By comparing two preliminary disease networks of PE and IUGR, we can identify components associated with the cross talks. We are preparing these maps using standard Systems Biology Markup Language (SBML) in CellDesigner.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska - Curie grant agreement No 765274.
 

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https://www.iplacenta.eu/