SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
+49 381 498-7571
iPlacenta: A Systems Biology Approach towards Phenotype-Specific Interactomes for Placental Function
Pre-eclampsia (PE) is a complex disorder occurring during pregnancy and the postpartum affecting almost 5-8% of all pregnancies and often occurs with other complications. Its pathology is largely unknown. To improve the diagnosis and treatment outcomes, a deeper understanding of the determinants of pathophysiology is urgently needed.
We are developing disease maps of PE and IUGR. We are using open source datasets to create a preliminary disease map, which will be enriched using heterogeneous data generated within the consortium. By comparing two preliminary disease networks of PE and IUGR, we can identify components associated with the cross talks. We are preparing these maps using standard Systems Biology Markup Language (SBML) in CellDesigner.
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Single extracellular vesicle analysis in human amniotic fluid shows evidence of phenotype alterations in preeclampsia
Gebara N, Scheel J, Skovronova R, Grange C, Marozio L, Gupta S, Giorgione V, Caicci F, Benedetto C, Khalil A, Bussolati B
Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved
Loscalzo G, Scheel J, Ibañez-Cabellos J S, García-Lopez E, Gupta S, García-Gimenez J L, Mena-Mollá S, Perales-Marín A, Morales-Roselló J
Placental mitochondrial function as a driver of angiogenesis and placental dysfunction
Correia Y, Scheel J, Gupta S, Wang K
De Gruyter BioChem (2021)