LOgo SBI Uni Rostock

SBI – Department of Systems Biology and Bioinformatics
Faculty of Computer Science and Electrical Engineering
University of Rostock
Ulmenstrasse 69 | 18057 Rostock
Germany
  +49 381 498-7571
  olaf.wolkenhauer@uni-rostock.de

iPlacenta: A Systems Biology Approach towards Phenotype-Specific Interactomes for Placental Function

iPlacenta: A Systems Biology Approach towards Phenotype-Specific Interactomes for Placental Function

Pre-eclampsia (PE) is a complex disorder occurring during pregnancy and the postpartum affecting almost 5-8% of all pregnancies and often occurs with other complications. Its pathology is largely unknown. To improve the diagnosis and treatment outcomes, a deeper understanding of the determinants of pathophysiology is urgently needed.

We are developing disease maps of PE and IUGR. We are using open source datasets to create a preliminary disease map, which will be enriched using heterogeneous data generated within the consortium. By comparing two preliminary disease networks of PE and IUGR, we can identify components associated with the cross talks. We are preparing these maps using standard Systems Biology Markup Language (SBML) in CellDesigner.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska - Curie grant agreement No 765274.
 
 
 
A step by step tutorial can be found here.
 

Visit our official Project-Website:

https://www.iplacenta.eu/

Related publications

Single extracellular vesicle analysis in human amniotic fluid shows evidence of phenotype alterations in preeclampsia

Gebara N, Scheel J, Skovronova R, Grange C, Marozio L, Gupta S, Giorgione V, Caicci F, Benedetto C, Khalil A, Bussolati B

bioRxiv (2022)

DOI: https://doi.org/10.1101/2022.02.14.480331

URL: https://www.biorxiv.org/content/10.1101/2022.02.14.480331v1

Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved

Loscalzo G, Scheel J, Ibañez-Cabellos J S, García-Lopez E, Gupta S, García-Gimenez J L, Mena-Mollá S, Perales-Marín A, Morales-Roselló J

IJMS (2021)

DOI: https://doi.org/10.3390/ijms23010293

URL: https://www.mdpi.com/1422-0067/23/1/293

Placental mitochondrial function as a driver of angiogenesis and placental dysfunction

Correia Y, Scheel J, Gupta S, Wang K

De Gruyter BioChem (2021)

DOI: https://doi.org/10.1515/hsz-2021-0121

URL: https://www.degruyter.com/document/doi/10.1515/hsz-2021-0121/html

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