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Biological Systems: Ras/Raf/Mek/ERK pathway

The Ras-Raf-MEK-ERK pathway is regulated by protein interactions and embedded in signalling networks.





A crucial regulator of this pathway is RKIP (Raf Kinase Inhibitor Protein).





RKIP converts the activation of the pathway into a switch-like response.

MEK activation
ERK activation
Biological Systems: JAK-STAT pathway
  • Ligand binding activates the receptor bound kinase JAK2 resulting.in phosphorylation of the receptor

  • STAT5 is recruited to the receptor, is phosphorylated, dimerizes and migrates to the nucleus

  • CIS, a direct target gene, is induced and negatively regulates.the JAK2-STAT5 pathway
    JAK2-STAT5 signaling pathway is.deregulated in multiple tumors